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The grandmother of a boy who went missing in 2011 from Illinois said she believes her grandson is still alive and hopes publicity surrounding a hoax will generate new leads.

Beginning on July 1, Illinois will join California, New Jersey, Massachusetts, Oregon, Hawaii, Maine and Washington, D.C. in banning tobacco sales to those under 21.

The James R. Thompson Center has been controversial since it landed in the Loop in 1985. Now, a new layer of controversy has been added to the building’s history: its potential sale.

Food allergies are on the rise, affecting 32 million Americans. Yet local clinicians are optimistic about future treatments, including one that could soon receive FDA approval.

The findings from the Ethiopian government provide the clearest link yet to a similar crash involving the same Boeing model plane in the waters off Indonesia in October. All 346 on board the two flights died.

High-end designers have always been eager to dress the superstar soprano for both stage roles and concert performances. Renée Fleming tells us about those one-of-a kind creations.

“I worry about our children growing up with so much trauma and fear. I worry about that a lot,” Mayor-elect Lori Lightfoot said during a one-on-one interview Friday with WTTW News.

A 23-year-old ex-convict accused of pulling a cruel hoax by pretending to be long-missing Illinois boy Timmothy Pitzen was charged Friday with making false statements to authorities.

Lori Lightfoot secures a historic election. City Council moves to the left. Cook County State’s Attorney Kim Foxx faces more heat. And the Cubs’ bullpen implodes.

Paris Schutz and guests discuss the loose ends in the final weeks of Mayor Rahm Emanuel’s term, including the Lincoln Yards TIF and the new police and fire academy.

Two Chicago police officers are in stable condition after their squad vehicle was struck overnight by an alleged drunk driver who ran a red light in the Lakeview neighborhood.

This spring season, Chicago theaters are in full bloom. Theater critic Hedy Weiss recommends new shows on Chicago-area stages, from fun musicals to serious dramas.

Police Superintendent Eddie Johnson weighs in on the Jussie Smollett investigation, and how he’ll work with Mayor-elect Lori Lightfoot.

A South Side native watches her long-forgotten home movies for the first time in 35 years. What was on them – and how the viewing was made possible.

What do seniors want from Chicago Mayor-elect Lori Lightfoot? A new survey offers her a wish list.

To the delight of some advocacy groups and the Chicago Teachers Union, state representatives voted Thursday to move Chicago to an elected school board structure.

Watch the April 4, 2019 full episode of “Chicago Tonight.”

Ald. Ed Burke, arguably City Council’s most powerful member for much of his 50-year reign, had various ways of dishing out perks and favors to colleagues. One of those, apparently, was to help some aldermen pay their bills.

The city of Chicago says Jussie Smollett has refused to pay more than $130,000 to reimburse costs of investigating what authorities say was a staged racist, anti-gay attack.

“Ms. Foxx needs to resign and she should do it quickly,” Chicago police union President Kevin Graham said at a press conference Thursday afternoon.

State Rep. Melissa Conyears-Ervin on Tuesday easily defeated 47th Ward Ald. Ameya Pawar in the runoff election for city treasurer. She joins us to discuss her victory and plans for the office.

DNA tests disproved a teenager’s claim that he was an Illinois boy who disappeared eight years ago, the FBI said Thursday, dashing hopes that the baffling case had finally been solved.

The city’s gleaming skyline and its position along a busy migratory corridor make it the most dangerous in the U.S. for birds traveling north and south each fall and spring, a new study finds.

New imaging techniques will allow researchers to study small changes in the retina that could indicate the early stages of brain diseases, like Alzheimer’s and Parkinson’s.

This edgy new play by Sharyn Rothstein, making its world premiere at Northlight Theatre, deals with the most primal human needs – for shelter, security, a sense of self-worth and love.

Lori Lightfoot’s victory in the Chicago mayor’s race signaled hope among voters that the nation’s third-largest city may someday move beyond long-entrenched divides.