The U.S. and Israel launched the war Saturday, targeting Iran’s leadership, missile arsenal and nuclear program while suggesting that toppling the government is a goal. But the exact aims and timelines have repeatedly shifted, signaling an open-ended conflict.

The war has killed more than 1,000 people in Iran, more than 70 in Lebanon and around a dozen in Israel, according to officials in those countries. It has disrupted the supply of the world’s oil and gas, snarled international shipping and stranded hundreds of thousands of travelers in the Middle East.

The cuts, imposed by the Trump administration, will hit the county’s bottom line next year, threatening the ability of more than 400,000 Cook County residents to get necessary health care.

Four days into a war that President Donald Trump suggested would last several weeks but perhaps longer, nearly 800 people have been killed in Iran, including some Trump said he had considered as possible future leaders of the country.

The war in the Middle East spiraled further Monday as Israel and the U.S. pounded Iran. Tehran and its allies hit back against Israel and targets critical to the world’s production of oil and natural gas.

Oil prices climbed, and stock markets slipped Monday as investors and households got the first chance to see what the war in the Middle East could mean for their finances.

Washington has a long, complicated past when it comes to regime change. There was Vietnam in the 1960s and 70s, and Panama in 1989. There was Nicaragua in the 1980s, Iraq and Afghanistan in the years after 9/11, and Venezuela just weeks ago.

Iranian authorities say more than 200 people have been killed since the start of the strikes that killed Ayatollah Ali Khamenei and other senior leaders. The U.S. military said three service members have been killed, the first known American casualties from the conflict.

Iran retaliated by firing missiles and drones toward Israel and U.S. military bases in the region, and exchanges of fire continued into the night.

While presidents have the authority as the commander in chief to conduct certain strategic military operations on their own, the Constitution vests Congress with the power to wage war.

The remarks by two Iranian officials come as America has assembled its biggest deployment of aircraft and warships to the Middle East in decades. The buildup is part of President Donald Trump’s efforts to get a deal to constrain Iran’s nuclear program while the country struggles at home following nationwide protests.

President Donald Trump has delivered the State of the Union. Now the challenge for him is to make that message stick.

Last week, the Trump administration delivered a catastrophic blow to U.S. climate policy by repealing the longstanding scientific finding that planet-warming pollution poses a danger to humans. Now comes the yearslong race through the courts.

“It’s only gotten more complicated for everybody,’’ said trade lawyer Ryan Majerus, partner at King & Spalding and a former U.S. trade official.

Several Democratic members of the Illinois congressional delegation have announced they would not attend the speech, citing their disapproval of the president.

The University of Chicago is among dozens of universities and colleges that have agreed to terminate their partnerships with a nonprofit that helps students from underrepresented groups get degrees in business.