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In this Jan. 5, 2020, file photo Democratic presidential candidate, former Vice President Joe Biden high-fives a member of the audience during a campaign rally at Modern Woodmen Park in Davenport, Iowa. (AP Photo / Andrew Harnik, File)

Joe Biden has formally clinched the Democratic presidential nomination, setting him up for a bruising challenge to President Donald Trump that will play out against the unprecedented backdrop of a pandemic, economic collapse and civil unrest.

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Chicago Mayor Lori Lightfoot joins Democratic presidential candidate Joe Biden and other mayors Monday, June 1, 2020 to discuss protests in the wake of the police killing of George Floyd in Minneapolis. (Joe Biden / YouTube)

Referencing Chicago’s own “dark days” with police violence, the mayor said additional training and improved relationships between officers and the community are needed following protests and looting across the city.

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Former President Barack Obama delivers a video message in January 2017 (Courtesy whitehouse.gov); and former Vice President Joe Biden speaks at Northwestern University in Chicago on March 9, 2018. (Evan Garcia / WTTW News)

Former President Barack Obama endorsed Joe Biden for president in a video message Tuesday that delivered a full-throated condemnation of President Donald Trump’s handling of the coronavirus pandemic.

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Illinois’ top Democrats coalesce behind Joe Biden in the presidential primary. Bernie Sanders plans a Grant Park rally. A sixth person tests positive for the coronavirus in Illinois. And the police union votes for a new leader.

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Democratic presidential candidate former Vice President Joe Biden addresses the Rainbow PUSH Coalition Annual International Convention Friday, June 28, 2019, in Chicago. (AP Photo / Charles Rex Arbogast)

Joe Biden strongly defended his civil rights record on Friday, pledging to be a “president who stands against racism” and “the forces of intolerance” and defiantly dismissing any suggestions otherwise.

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Former Vice President Joe Biden speaks at Northwestern University on March 9. (Evan Garcia / Chicago Tonight)

Amid increasing speculation over a possible run for president in 2020, the former vice president delivered a speech Friday at Northwestern University. See photos from the event.

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Former Vice President Joe Biden weighs in on the current state of affairs and on the threat posed by Russia during a speech in Chicago. Is he laying the groundwork for 2020?

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Vice President Joe Biden talks with professor Robert Grossman, director of Center for Data Intensive Science at the University of Chicago, and Louis M. Staudt of the National Cancer Institute as they tour the Genomic Data Commons on June 6. (Robert Kozloff)

Cancer researchers will have an easier time accessing, sharing and analyzing information with the launch Monday of a new platform funded by the National Cancer Institute.

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Vice President Joe Biden has run for president of the U.S. twice, most recently as an early Democratic contender in the 2008 primary. A Chicago-based movement called Draft Biden is hoping he’ll run once more.

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A debate that might have been little more than a side note has now taken on greater significance. We preview tonight's face-off between Vice President Joe Biden and Congressman Paul Ryan.