Stories by Associated Press

The national average gas price was $3.48 a gallon on Monday, up from $2.90 a month ago, before the war, according to tracking by AAA.

It’s a major step back from comments made at a White House news conference in September, when Trump and FDA commissioner Marty Makary announced the drug was under review to benefit patients with autism.

Iran named the hard-line Ayatollah Mojtaba Khamenei to succeed his late father as supreme leader on Monday, signaling no letup in the war launched by the United States and Israel. 

There was no sign of the war letting up on its seventh day, as U.S. President Donald Trump appeared to rule out negotiations with Iran and called for its “unconditional surrender.“

Kristi Noem is the first Cabinet secretary to leave during Trump’s second term. Her departure caps a tumultuous tenure overseeing immigration enforcement tactics that have been met with protests and lawsuits.

The war has escalated each day, affecting an additional 14 countries across the Middle East and beyond.

The war has killed more than 1,000 people in Iran, more than 70 in Lebanon and around a dozen in Israel, according to officials in those countries. It has disrupted the supply of the world’s oil and gas, snarled international shipping and stranded hundreds of thousands of travelers in the Middle East.

The war powers resolution gave lawmakers an opportunity to demand congressional approval before any further attacks are carried out. The vote forced them to take a stand on a war shaping the fate of U.S. military members, countless other lives and the future of the region.

Four days into a war that President Donald Trump suggested would last several weeks but perhaps longer, nearly 800 people have been killed in Iran, including some Trump said he had considered as possible future leaders of the country.

Homeland Security Secretary Kristi Noem testified in the Senate on Tuesday in her first congressional appearance since the shooting deaths of two protesters in Minneapolis galvanized widespread opposition to how the Trump administration was executing its mass deportation agenda.

The war in the Middle East spiraled further Monday as Israel and the U.S. pounded Iran. Tehran and its allies hit back against Israel and targets critical to the world’s production of oil and natural gas.

Oil prices climbed, and stock markets slipped Monday as investors and households got the first chance to see what the war in the Middle East could mean for their finances.

Washington has a long, complicated past when it comes to regime change. There was Vietnam in the 1960s and 70s, and Panama in 1989. There was Nicaragua in the 1980s, Iraq and Afghanistan in the years after 9/11, and Venezuela just weeks ago.

Iranian authorities say more than 200 people have been killed since the start of the strikes that killed Ayatollah Ali Khamenei and other senior leaders. The U.S. military said three service members have been killed, the first known American casualties from the conflict.

Iran retaliated by firing missiles and drones toward Israel and U.S. military bases in the region, and exchanges of fire continued into the night.

While presidents have the authority as the commander in chief to conduct certain strategic military operations on their own, the Constitution vests Congress with the power to wage war.

Since the 1990s, the FDA has collected fees from drug companies to help pay for extra staffers to quickly review new prescription drugs and vaccines. Under the agreement with the industry, the FDA has timelines and metrics for completing each review.

The remarks by two Iranian officials come as America has assembled its biggest deployment of aircraft and warships to the Middle East in decades. The buildup is part of President Donald Trump’s efforts to get a deal to constrain Iran’s nuclear program while the country struggles at home following nationwide protests.

President Donald Trump has delivered the State of the Union. Now the challenge for him is to make that message stick.

“It’s only gotten more complicated for everybody,’’ said trade lawyer Ryan Majerus, partner at King & Spalding and a former U.S. trade official.

The killing of Nemesio Oseguera Cervantes during an attempt to capture him in Jalisco state was the highest-profile blow against cartels since the recapture of former Sinaloa cartel boss Joaquín “El Chapo” Guzmán a decade ago.

House Speaker Mike Johnson’s office said it received a request from the family to have Jackson’s remains lie in honor at the Capitol, but the request was denied, because of the precedent that the space is typically reserved for former presidents, the military and select officials.

 The Supreme Court struck down President Donald Trump’s far-reaching global tariffs on Friday, handing him a significant loss on an issue crucial to his economic agenda.

The two-study standard for drugs dates to the early 1960s, when Congress passed a law requiring the FDA to review data from “adequate and well-controlled investigations” before clearing new medications.

The Rev. Jesse L. Jackson led a lifetime of crusades in the United States and abroad, advocating for the poor and underrepresented on issues from voting rights and job opportunities to education and health care.

Robert Duvall, the Oscar-winning actor whose classic roles included the intrepid consigliere of the first two “Godfather” movies and the over-the-hill country music singer in “Tender Mercies,” has died at age 95.