A promising new treatment for sickle cell anemia, developed by the National Institutes for Health and validated by a new study by the University of Illinois at Chicago, holds out the prospect of a cure for this chronic disease. Dr. Santosh Saraf, one of the co-authors of the UIC study, joins us to discuss these groundbreaking developments.

Block 37 has a new attraction, but you'd better stop for lunch before you go. The Foodseum celebrates the city's love of all things edible with an exhibit that highlights hot dogs and encased meats from around the globe. We visited the pop-up museum to learn more.

Jeannie Morris might be better known for her groundbreaking career as one of the first female sports journalists, but in her new book "Behind the Smile: A Story of Carol Moseley Braun's Historic Senate Campaign," she tackles national politics and unveils the ups and downs of Moseley Braun’s life and career. Morris joins us tonight to discuss the book.

Jay Shefsky goes kayaking where paddlers rarely go – the busy and industrial Calumet River. See what he discovered while tagging along with a couple of local kayakers who regularly venture into the hard working river.

Mayor Rahm Emanuel on Tuesday unveiled his proposed 2016 budget. Included is a $543 million property tax increase that would be phased in, beginning with a $318 million hike this year. Fees on garbage collection and ride-sharing services – including taxis – and a new tax on e-cigarettes aim to plug the city's budget hole.

How do we make decisions? Can we learn better reasoning skills? Those are questions University of Michigan psychologist Richard Nisbett has spent his life studying. He joins us tonight to discuss his new book, "Mindware: Tools for Smart Thinking.”

Judy Collins recounts her long music career and her political activism, which included testifying in Chicago in 1969 in support of the Chicago Seven. 

Illinois is coming up on almost three months with no state budget, and Republican Gov. Bruce Rauner and Democratic legislative leaders don't appear to be any closer to a solution. Two lawmakers known for sometimes bucking their party leaders discuss whether there's a bipartisan path out of the state's current mess.

The Carson Palmer-led Cardinals marched convincingly through Soldier Field on Sunday, with the Bears defense hardly able to break their stride. The Bears had never given up as many as 48 points in a home game – until now. Former Bear James "Big Cat" Williams joins Ann Kreiter to give us his take on the second game of the season.

Pulitzer Prize-winning architecture critic Blair Kamin of the Chicago Tribune walks us through the new designs for the Lucas Museum. Learn about the details of Chinese architect Ma Yansong's revised plan for the potential lakefront museum – and what is missing.

Chicago-based business writer Bethany McLean makes the case that mortgage giants Fannie Mae and Freddie Mac are in a precarious state in her new book, "Shaky Ground: The Strange Saga of the U.S. Mortgage Giants." She'll explain what failure could mean for American mortgage holders when she joins us Monday on "Chicago Tonight."