After 41 years in public service, Illinois Senate President John Cullerton is stepping down. He reflects on recent headlines, his life in politics and what’s next.

The American Cancer Society reported last week the largest ever single-year decline in deaths from cancer. How improved disease screening and breakthrough treatments are giving cancer patients new hope.

Chicago’s popular 606 trail has led to skyrocketing property values in the surrounding area. Several aldermen now say they want to hit pause on some development because it’s leading to displacement of longtime residents. But the plan has its critics.

As artificial intelligence becomes more widespread, the White House lays out best practices for developing and using the technology.

As the city continues its work to bring down the homicide rate following a 2016 spike, Chicago’s interim police superintendent believes one thing is absolutely necessary: winning back the public’s trust.

There’s a new library in Chicago and it’s stocked with pretty much everything except books. We visit the Chicago Tool Library in Bridgeport.

Jewel-Osco’s corporate parent is expected to announce in a few weeks whether it will proceed with an initial public offering of stock, which could be valued at around $19 billion. 

Watch the Jan. 13, 2020 full episode of “Chicago Tonight.”

House Speaker Michael Madigan rebuffed a call by his Republican counterpart to convene a special House committee to investigate an alleged “criminal cover-up” detailed in an email written by one of Madigan’s top confidants.

It’s the latest in a string of tragic news involving Chicago-based Boeing: A 737 jet crashed Wednesday, killing all 176 people on board. We discuss that incident and what the future holds for Boeing with Tracy Rucinski, U.S. aviation correspondent for Reuters.

The city is on high alert after two coyote attacks Wednesday, but a wildlife expert says such incidents are very rare. “I don’t think people need to be panicked or alarmed,” said Seth Magle, director of the Urban Wildlife Institute at Lincoln Park Zoo.

The U.S. stock market closed at record highs Thursday, indicating investor confidence as relations between the U.S. and Iran appear to cool down. Ed Stuart and Michael Miller share their thoughts on current economic conditions.

A Texas developer is set to make a bold bet in the Fulton Market District and hoping to help jumpstart Chicago’s life-sciences industry in the process.