Researchers in the fight against Alzheimer’s may have found a way to detect the disease early on. They discovered small toxins related to Alzheimer’s, which builds up in the brain, attacking the brain’s memory centers. Collaborators  are trying to discover a way to protect the brain from these toxins, or even better, prevent them from building up in the first place. Dr. William Klein, an Alzheimer’s disease researcher at Northwestern University, joins us with details. Read facts and figures about Alzheimer's disease and watch a video.

Catholic school enrollment rises for the first time in years. The rise comes as Chicago Public Schools lose 3,000 students. Elizabeth Brackett has the story. Read an article.

Bruce Springsteen’s right-hand man Steven Van Zandt joins us for a wide-ranging discussion about the Boss, The Sopranos, and why he thinks The Rascals is one of the greatest American bands ever. View a behind-the-scenes slideshow of Van Zandt's visit to our studio and watch a web extra conversation.

Delve into an epic 33-pound book by the artist and naturalist, John Audubon. Birds of America is getting its first complete reproduction by a Chicago gallery owner more than 150 years after its first printing. View a slideshow.

We share what you had to say about this week’s stories in tonight’s viewer feedback.

A very bumpy start to the CTA's new Ventra payment system has forced the transit agency to change gears. We hear what some passengers have to say, and get the latest on the CTA's newly revised plan. Read an article and share your thoughts.

Want to know how Cook County Jail keeps track of its inmates? Through hundreds of thousands of pieces of tattered paper. Paris Schutz has more on why Sheriff Tom Dart says it's a disaster waiting to happen. Read letters from Circuit Court Clerk Dorothy Brown to Dart.

A newly redesigned $100 bill went into circulation on Tuesday. With a new paper blend, modernized security features and an updated portrait of Benjamin Franklin, the new bill will be more difficult to counterfeit. See photos and security features of the new bill.

A Chicago landmark is undergoing a renaissance as a luxurious hotel on Michigan Avenue. We take a peek under the dust in tonight's Ask Geoffrey.

Dan Parizek is a “Honeybee Rescuer." If you’ve got a beehive in the walls of your home, Dan will relocate it so it won’t be destroyed by an exterminator. With Colony Collapse Disorder destroying some 10 million beehives since 2007, Dan and others say we can’t afford to lose any more hives. We revisit Jay Shefsky's profile. Read an article, watch a web extra video, and learn more about Colony Collapse Disorder from local scientists.

Chicago was recently named as the host city for the 27th edition of the 2015 World Triathlon Grand Final. Elizabeth Brackett has won four World Championship titles and placed second in this year’s London World Championships. Watch a web extra video about what Chicago can expect when it hosts the World Championships in 2015.

GOP governor candidates have now all selected running mates. But are they qualified to be governor in an emergency? Paris Schutz has the latest. View a graphic of Illinois gubernatorial candidates and their running mates.

The Supreme Court’s new term started the first Monday in October. The court docket includes hot-button cases on political campaign contributions, abortion rights, free speech, affirmative action, public prayer and presidential power. We hear from three former Supreme Court clerks about the issues before the court and how cases are chosen.