Researchers in the fight against Alzheimer’s may have found a way to detect the disease early on. They discovered small toxins related to Alzheimer’s, which builds up in the brain, attacking the brain’s memory centers. Collaborators  are trying to discover a way to protect the brain from these toxins, or even better, prevent them from building up in the first place. Dr. William Klein, an Alzheimer’s disease researcher at Northwestern University, joins us with details. Read facts and figures about Alzheimer's disease and watch a video.

Catholic school enrollment rises for the first time in years. The rise comes as Chicago Public Schools lose 3,000 students. Elizabeth Brackett has the story. Read an article.

Bruce Springsteen’s right-hand man Steven Van Zandt joins us for a wide-ranging discussion about the Boss, The Sopranos, and why he thinks The Rascals is one of the greatest American bands ever. View a behind-the-scenes slideshow of Van Zandt's visit to our studio and watch a web extra conversation.

Guitarist for the E Street Band, Little Steven Van Zandt, visited us in studio to talk about being an underboss to the Boss, James Gandolfini and The Sopranos, and reviving one of his favorite bands, The Rascals.

Delve into an epic 33-pound book by the artist and naturalist, John Audubon. Birds of America is getting its first complete reproduction by a Chicago gallery owner more than 150 years after its first printing. View a slideshow.

We share what you had to say about this week’s stories in tonight’s viewer feedback.

Joel Weisman and his panel of journalists discuss the week's top headlines.

Joel Weisman and his panel of journalists take a closer look at the picks for Lieutenant Governor by Republican gubernatorial hopefuls. Watch the web extra video.

A Civil War exhibit, food trucks, and the Chicago Marathon; Chicago Tonight knows what's going on this weekend.

A new rock record by a Chicago-based band is led by a dynamic vocalist who chronicles the experience of a South Asian immigrant. American Desi by the band Clara May might remind you of David Bowie or Robert Plant’s solo work at times, but Clara May stakes new ground with a unique point-of-view and an epic soundscape.

The city is in final preparations for the Chicago Marathon this weekend. But will it be safe in light of what happened in Boston? Paris Schutz has the details. View a route map and information on street closures.

Cook County Board President Toni Preckwinkle joins us to discuss some major reforms proposed in the county's 2014 budget. Read her budget recommendations.

Best-selling author Bill Bryson joins us to discuss his newest book, One Summer: America, 1927. Read an excerpt.

Television producer, inspirational speaker and founder of The Adelante Movement Nely Galán hosts her national tour in Chicago this weekend. The Adelante Movement seeks to unite and empower women economically. The event will feature inspirational speakers, business workshops, networking sessions, and personal and financial business advice. Read an interview.

A book called How We Do It: The Evolution and Future of Human Reproduction explores the science of sex and childbirth. We revisit a conversation with the book's author. Read an excerpt.