Yingying Zhang disappeared in June. Now, attorneys for the man accused in her kidnapping and death are requesting a delay in the trial, in part because they want to investigate possible sightings of the victim.

Northwestern University scientists believe they may have found the “Achilles’ heel” of cancer. In a recent study, researchers were able to almost completely eradicate the disease in laboratory cell cultures.

The EPA likely won’t be able to determine the source of a late October oil spill in the Chicago River because the agency was notified about the spill two days after it occurred, the EPA said Tuesday. 

A Chicago Public Schools watchdog report recommended her termination just two months ago, but on Thursday, York Alternative High School Principal Sharnette Sims received an apology from the district and was told she’ll be reinstated to her position, effective immediately.

It’s not mandatory by law yet, but Illinois legislators began formal lessons Wednesday on how to conduct themselves without “unwelcome” behavior and contacts that could be perceived by victims as sexual harassment. 

The city’s military academies help some Chicago Public Schools students reach new heights. We visit Air Force Academy High School.

Grammy winner and Chicago native Chance the Rapper showed up at Wednesday’s City Council meeting to give aldermen—and Mayor Rahm Emanuel—a piece of his mind.

Watch the Nov. 8, 2017 full episode of "Chicago Tonight."

The city’s former deputy mayor in charge of neighborhood redevelopment talks about her new role as CEO of World Business Chicago.

President Donald Trump this week again claimed—erroneously—that Chicago has the “strongest gun laws in our nation,” pushing back against the idea the tough legislation will reduce gun violence.

Geoffrey Baer gets ready for a new voyage along the Chicago River with viewer questions about the history of our city’s favorite Y-shaped waterway.

He holds the American record for most consecutive days in space. Retired astronaut Scott Kelly discusses the incredible mission described in his new book, “Endurance: A Year in Space, A Lifetime of Discovery.”

Veterans Day salutes, rock ‘n’ roll movies, “rebellious” artists, indigenous cuisine, top-notch dancers and wild animals usher in the weekend. Here are 10 things to do in Chicago.

Responding to local officials’ call for restrictions on opioid prescriptions, the American Dental Association outlines the steps it’s taking to address the opioid epidemic. 

Sexual harassment has been part of the way of life at the Illinois state capital for decades. Lawmakers on Tuesday spent much of the day decrying that culture and approving measures intended to root it out.