The human voice is a remarkable instrument. And when the 115 heavenly souls of the Chicago Symphony Chorus gather on stage with the musicians of the Chicago Symphony Orchestra, something extraordinary happens.

The grocery store chain released more details this week about its plans to phase out a practice that animal welfare advocates consider inhumane. 

Pritzker wins big. Rauner squeaks by in what could be the costliest race for governor ever. Garry McCarthy announces and Rahm Emanuel pounces. And the Ramblers ramble on.

Eddie Arruza and guests discuss the 3rd Congressional District candidate described by his party as a neo-Nazi.

Students calling for an end to gun violence will lead hundreds of marches across the country this weekend. Meet a Chicago teen invited to speak at the national March For Our Lives event in Washington, D.C.

As has become the norm in the Loyola Rambler’s heart-pounding NCAA Tournament run, it came down to the final seconds on Thursday against the Nevada Wolf Pack.

Your thoughts about the potential ramifications of a Chinese company drawing 7 million gallons of water a day out of Lake Michigan.

Garry McCarthy is officially in. “It’s time for new leadership in City Hall that’ll fix our problems and pull us together,” the former Chicago Police superintendent said in a video announcing his bid for Chicago mayor.

Watch the March 22, 2018 full episode of "Chicago Tonight."

Health and Human Services Deputy Secretary Eric Hargan discusses his agency’s role in combating the opioid crisis.   

China faces steep tariffs for allegedly stealing U.S. intellectual property. Is a trade war in the offing?

One thing we can all count on in Chicago is the late winter and early spring pothole season. We catch up with some city crews trying to make life a little less bumpy.

Cook County Sheriff Tom Dart drew national attention when he appointed a psychologist to be the jail’s executive director. After almost three years on the job, Nneka Jones Tapia is moving on. 

Geoffrey Baer travels to France to meet this year’s winners of the Driehaus Prize for architecture.

Alaina Hampton, a former political and legislative staffer in House Speaker Michael Madigan’s political organization, is taking her ex-boss to federal court.