Under pressure from moderates in both parties, House Speaker Nancy Pelosi and Senate Majority Leader Mitch McConnell have initiated late-game negotiations. Here are the top issues for the end-stage COVID-19 relief talks.

Illinois expects to get 109,000 doses of a COVID-19 vaccine developed by Pfizer if federal officials grant an emergency use authorization to the pharmaceutical company as expected, Gov. J.B. Pritzker said Friday.

The nation’s unwillingness to tamp down on travel offered a warning in advance of Christmas and New Year’s as virus deaths and hospitalizations hit new highs a week after Thanksgiving.

In the coming weeks, the social network will begin taking down any Facebook or Instagram posts with false information about the vaccines that have been debunked by public health experts.

The Holiday Train’s appearances are more spontaneous than in recent years, with no tracker available. That’s left some folks feeling cranky. 

By targeting health care providers with attacks that scramble and lock up data until victims pay a ransom, hackers can demand thousands or millions of dollars and wreak havoc until they’re paid.

This winter we’re in for a La Nina cycle, which is known for increased storminess and has produced some wild weather over the years.

As residents and businesses grapple with the coronavirus, a new health center opens on the South Side. Amanda Vinicky reports from Chatham.

Grammy Award-winning jazz singer Kurt Elling said he’s played the storied venue so much, he’s able to imagine a live audience during his virtual performances.

The president-elect has frequently emphasized mask-wearing as a “patriotic duty” and during the campaign floated the idea of instituting a nationwide mask mandate.

As Illinois continues dealing with its deadliest stretch of the coronavirus pandemic to date, state health officials are calling on those who’ve had COVID-19 to consider donating plasma as it may help those who are actively fighting the disease.

There is enough evidence to warrant a trial for an Illinois 17-year-old accused of killing two men and wounding a third during a night of unrest in Wisconsin, a court commissioner ruled Thursday.

The U.S. recorded over 3,100 COVID-19 deaths in a single day, obliterating the record set last spring, while the number of Americans in the hospital with the virus has eclipsed 100,000 for the first time, according to figures released Thursday.

The mayor was asked about her stance on the practice of claiming a shoveled-out parking space. And her answer managed to thread a political needle.

Watch the Dec. 3, 2020 full episode of “Chicago Tonight.”