An eyewitness recounts what she saw in Las Vegas on Sunday night during what has become the deadliest mass shooting in modern U.S. history.

Meet one of the first African-American flight attendants and hear the unusual way her mother inspired her love of travel.

More than 125 animal welfare experts from around the world will gather in October to share new research and best practices related to caring for animals in zoos and aquariums.

Can Illinois stop the spread of HIV infections? A statewide initiative aims to do just that. “We have a real chance of stopping the spread of HIV once and for all,” Mayor Rahm Emanuel said.

The likelihood of correctly calling 14 coin tosses in a row is 1 in 16,384—or about as likely as Bears fans longing for the return of Rex Grossman. In light of the Bears’ current streak, we crunch the numbers.

A miniature female reproductive system will help researchers better understand the cause of polycystic ovary syndrome, and advance the development of drugs to treat the disease.

Attorneys for Brendan Dassey discuss interrogation techniques and environmental factors that can leave a suspect feeling like they have no choice but to confess – even if they’re innocent.

The governor signs a controversial bill. Chicago cops mimic NFL player protests. City leaders push hard for Amazon headquarters. Chicago native Hugh Hefner dies at age 91. And the Cubs clinch their division for the second straight year. 

Mayor Rahm Emanuel says the city is suing consumer reporting agency Equifax after last month’s massive breach that exposed 143 million consumers to possible identity theft—including 5.4 million Illinoisans.

Watch the Sept. 28, 2017 full episode of "Chicago Tonight."

What brought about the new business arrangement of two of Chicago’s most prominent cultural institutions? We speak with two of the driving forces behind each company.

An Illinois case will be heard by the U.S. Supreme Court, and it could have huge ramifications for public unions.

The move puts an end to ambiguity over his stance on the issue, but in raising the ire of his conservative base it may also force him into a new battle: fending of a challenger from the right in next year’s elections.

A who’s who of great artists and writers of the 20th century was influenced by one who died in semi-obscurity nearly 200 years ago.

Since embarking on a new sustainability initiative, Shedd Aquarium has cut annual water use by more than half, from 60 million gallons in 2012 to 28 million gallons today.