The U.S. government is spending $3 million to find out if marijuana can relieve pain, but none of the money will be used to study the part of the plant that gets people high.

A cheap, daily pill that combines four drugs has been tested for the first time in the United States to see if it works as well among low-income Americans as it has in other countries to treat conditions leading to heart attacks and strokes.

The government’s intelligence watchdog is set to testify Thursday in a closed session before the House intelligence committee about the handling of a whistleblower complaint.

Are there early signs of a revolt that could make life harder for Chicago’s mayor? Our politics team takes on that story and more in our weekly roundtable.

Chicago poet Kevin Coval and illustrator Langston Allston discuss their new book about Wicker Park in the 1990s – and the forces of gentrification that have changed it.

About a decade ago, Chicago tried, and failed, to bring the 2016 Summer Olympics to the city. But it wasn’t the first time Chicago tried to host a major international sporting event. Geoffrey Baer explains.

Exhibits and installations from around the world hope to reframe – and sometimes challenge – the very idea of architecture at this year’s event. We get a preview.

The National Suicide Prevention Lifeline is 1-800-273-TALK. But the FCC wants to make that number a whole lot easier to remember – and dial.

A relatively nondescript seven-story office building in the Fulton Market District has become the most expensive office building sale in the city’s history.

A proposal to add a so-called greenway for cyclists and introduce pedestrian-focused safety measures on a Lincoln Park side street has sparked an outpouring of attention from neighbors.

Chicago’s mayor and aldermen are vowing to take strict action on vaping while welcoming the sale of cannabis. Those two vices dominated the discussion during Wednesday’s City Council meeting.

International artists, lucha libre wrestling, craft brews and cool jazz usher in the weekend. Here are 10 things to do in Chicago.

President Donald Trump on Wednesday named Robert O’Brien, his chief hostage negotiator and an established figure in Republican policy circles, as his new national security adviser.

Watch the Sept. 18, 2019 full episode of “Chicago Tonight.”

The new report illustrates that abortions are decreasing in all parts of the country, whether in Republican-controlled states seeking to restrict abortion access or in Democratic-run states protecting abortion rights.