Former Vice President Joe Biden weighs in on the current state of affairs and on the threat posed by Russia during a speech in Chicago. Is he laying the groundwork for 2020?

Local officials call for restrictions on opioid prescriptions as Mayor Rahm Emanuel proposes a $500,000 investment to fight the opioid epidemic.

Basketball kept Max Sansing and his friends out of trouble, but when the rims were removed from neighborhood parks and schools, their lives were changed. Now Sansing is using old backboards to tell that story.

Scientists say there are more bacteria in the ocean than stars in the universe, yet little is known about them. A new study outlines the “crazy idea” that led to a project described by one scientist as the “Google database for microbes.”

Lady arm wrestlers, a massive art fair, sudsy brews and sea lions usher in the weekend. Here are 10 things to do in and around Chicago.

Watch the Oct. 31, 2017 full episode of "Chicago Tonight."

We take a closer look at the race for governor in both parties, and the surprise candidate running for attorney general.

Lobbyist Denise Rotheimer, who is also running as a Republican for state representative, testified that she was the victim of “mind games” and untoward comments made by state Sen. Ira Silverstein, D-Chicago.

An investigation uncovers a disturbing gap in how much local communities charge their residents for water. We discuss the findings with Chicago Tribune reporters Cecilia Reyes and Ted Gregory.

Former President Barack Obama and first lady Michelle Obama are back home in Chicago to launch the inaugural Obama Foundation Summit. 

Up to this point, it wasn’t certain that a challenger would emerge from the intraparty revolution Gov. Bruce Rauner ignited when he signed an abortion law in late September. There’s no ambiguity now.

Walgreens and CVS try to fend off competition from Amazon. Reporter Bruce Japsen joins us for a look at possible shifts in the pharmacy business.

Supporters of a bill vetoed this summer by Gov. Bruce Rauner are calling on legislators to override that action next month in the hopes of expanding the use of gas tax funds to public transportation services and other improvements.

Former Northwestern professor Wyndham Lathem and his accomplice Andrew Warren, charged in the stabbing death of a Chicago hairstylist, will have their hearings scheduled together as their cases proceed.

Words of culinary wisdom from master pastry chef Jacquy Pfeiffer, co-founder of The French Pastry School.