Officials have identified about 450 possible cases, including as many as five deaths, in 33 states. The count includes newly reported deaths in California, Indiana and Minnesota.

Jury selection will begin Friday in the murder trial of two of three men charged with carrying out the November 2015 attack on Tyshawn Lee, a smart fourth-grader who prosecutors say was killed by gang members to send a message to his father, a purported member of a rival gang.

A judge rules Sterigenics can reopen. The mayor hears "no new property taxes" at her first budget town hall meeting. Elected officials spar over city violence. And the Bears blow the 100th season opener.

Telehealth, or the virtual delivery of health-related services, is on the rise. State and federal officials gave an update on investments supporting expansion of such services at an annual conference, including a $420 million expansion of broadband services in Illinois.

Latrice Harrell, executive director of The Champion Center for Autism Inc., faces the possibility of decades in prison after allegedly submitting $3 million in fraudulent insurance claims over the course of three years.

A federal judge overseeing litigation related to the nation’s opioid epidemic ruled Tuesday that lawsuits targeting Purdue Pharma and other drug companies can move to trial even as the OxyContin maker tries to reach a settlement.

Expect no flashy spectacle, lavish dance numbers or any of the other standard ingredients of Broadway musicals. But be assured that “The Band’s Visit” – now making a brief stop at the Cadillac Palace Theatre as part of its national tour – comes with its very own unique magic. 

Mitchell Trubisky and the Chicago Bears were shut down by the Green Bay Packers on Thursday night, losing 10-3 in an ugly NFL opener that showered cold water on any championship dreams in the Windy City.

Former President Barack Obama’s planned presidential center is still years from opening, but a new report suggests it may already be having an effect on the surrounding neighborhoods.

An interpretation of Chicago’s founders has been floating across the city in an effort to connect communities from Austin to Englewood. We explore the Floating Museum’s Cultural Transit Assembly.

The Chicago Teachers Union on Wednesday set a date for a strike authorization vote. It’s the latest turn in what’s been a contentious round of contract negotiations. CPS CEO Janice Jackson discusses that and more.

Marijuana sales for recreational use will be legal in Illinois come January, but not all cities in the state are on board. Two Naperville City Council members join us to discuss how that city is handling the change.

In her “State of the City” speech last week, Chicago Mayor Lori Lightfoot said she wants to reduce traffic congestion in the city – and make money in the process. Could congestion pricing come to Chicago?

How much do service members and civilians interact? Some say not enough. But a new podcast out of the University of Chicago aims to change that.

We visit The Conservation Center, the country’s largest private conservation lab, for a look at how they are rejuvenating an artful piece of Chinese history.